Breast Cancer Gene Expression Altered by Walnut Consumption

Breast Cancer Gene Expression Altered by Walnut Consumption (genengnews.com)

[Genetic Engineering & Biotechnology News, 3/29/19]  In a small clinical study, investigators from Marshall University School of Medicine found that the consumption of two ounces of walnuts per day for about two weeks significantly changed gene expression in confirmed breast cancers. The findings from the study were published recently in Nutrition Research through an article titled “Dietary walnut altered gene expressions related to tumor growth, survival, and metastasis in breast cancer patients: A pilot clinical trial.”

“Consumption of walnuts has slowed breast cancer growth and/or reduced the risk of mammary cancer in mice,”

explained lead study investigator W. Elaine Hardman, PhD, professor in the department of biomedical sciences at Marshall University. “Building on this research, our team hypothesized that walnut consumption would alter gene expression in pathologically-confirmed breast cancers of women in a direction that would decrease breast cancer growth and survival.”

This pilot, a two-arm clinical trial, is the latest in a series of related studies at Marshall University related to dietary walnut links to tumor growth, survival, and metastasis in breast cancer. In this first clinical trial, women with breast lumps large enough for research and pathology biopsies were recruited and randomized to walnut consuming or control groups. Immediately following biopsy collection, women in the walnut group began to consume two ounces of walnuts per day until follow-up surgery. Pathological studies confirmed that lumps were breast cancer in all women who remained in the trial. At surgery, about two weeks after biopsy, additional specimens were taken from the breast cancers…….


Read the Full Article at: Genetic Engineering & Biotechnology News

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