Epilepsy drugs linked to higher risk of birth defects, study says
Side effects of prescription drugs are of particular concern during pregnancy.
[CNN, 6/12/19Two medicines used to control epileptic seizures — and prescribed to patients with migraine, pain and bipolar disorder — are associated with an increased risk of birth defects, new research indicates.
Women who took valproic acid or topiramate in the early months of their pregnancies had a higher-than-usual chance of having babies with birth defects, including spina bifida and cleft lip, according to a study published Wednesday in Neurology.
2% of pregnant Americans use anti-epilepsy drugs
Anti-epileptic drugs, particularly the newest ones, are increasingly prescribed for medical conditions unrelated to epilepsy. Prevalence of epilepsy medicine use for any reason during pregnancy is reported as 21.9 per 1,000 expectant women in the United States, 6.7 per 1,000 in France and 4.3 per 1,000 in the Netherlands, according to a 2018 study cited by the researchers.
For the study, researchers used data from the French national health care system to identify pregnancies that resulted in live births between January 2011 and March 2015. Among the 1,886,825 pregnancies, the researchers looked for the mothers’ use of 10 anti-seizure drugs before and after conception and searched for 23 birth defects in the children born to these women……….
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