Hormonal contraception may cause bone loss in adolescent girls
[Healio, 1/11/19] Healthy adolescent girls exposed to combined hormonal contraception experienced less bone mineral density accrual at the lumbar spine over 24 months vs. those not exposed to hormonal birth control methods, according to findings from a systematic review and meta-analysis.
“This meta-analysis of prospective, controlled, observational studies of adolescent girls shows significant and clinically important spinal bone loss over 2 years in teens using combined hormonal contraception,” Jerilynn C. Prior, MD, FRCPC, professor of endocrinology and metabolism in the department of medicine at the University of British Columbia and founder and scientific director at the Centre for Menstrual Cycle and Ovulation Research in Vancouver, told Endocrine Today. “Instead of using combined hormonal contraception as the go-to, routine therapy in adolescent girls, we need to use evidence-based and physiological ways to treat cramps, heavy flow, irregular cycles and acne, and nonhormonal methods for contraception.”
Prior and colleagues analyzed data from nine open-label clinical trials and observational, longitudinal studies that included adolescent girls prescribed any combined hormonal birth control (including estrogen and progestin in oral, patch or ring preparation) or no intervention between 2014 and 2018. Included studies were conducted in Brazil, Canada, China and the United States and reported absolute BMD change over 1 and 2 years (measured via DXA). The researchers recorded pooled estimate of absolute change at the lumbar spine BMD site at 12 or 24 months of hormonal contraceptive use, or for a similar duration in control adolescent girls…………
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