Reduced Fertility in Obese Women May Be Related to Dysfunctional Insulin Pathway

[Endocrinology Advisor, 12/13/18]  A high body mass index (BMI) is associated with reduced follicle-stimulating hormone (FSH) receptor expression in human chorionic gonadotropins (hGCs), reduced expression of estradiol synthesis-related genes, and reduced production of estradiol, according to study results published in The Journal of Clinical Endocrinology & Metabolism.

Obesity is one of the underlying causes of reduced fertility in women, and assisted reproductive technology including in vitro fertilization is often less successful in women with infertility with elevated BMI. In this study, researchers investigated the underlying mechanisms of BMI-related associations with poor reproductive outcomes in obese women…………

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